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Top1/2-IN-1(compound 23)作为一种口服双重抑制剂,对Top1/2具有有效的抗增殖作用。该化合物能够随着活性氧水平的升高而破坏DNA,进而诱发癌细胞的凋亡和周期停滞。在异种移植模型中,Top1/2-IN-1展现了显著的体内抗肿瘤活性。
Top1/2-IN-1(compound 23)作为一种口服双重抑制剂,对Top1/2具有有效的抗增殖作用。该化合物能够随着活性氧水平的升高而破坏DNA,进而诱发癌细胞的凋亡和周期停滞。在异种移植模型中,Top1/2-IN-1展现了显著的体内抗肿瘤活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models. |
分子量 | 347.41 |
分子式 | C21H21N3O2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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