HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity

Halofuginone (HF)，一种广泛研究的febrifugine衍生物，在小鼠的多发性硬化症模型中通过激活氨基酸应答（AAR）途径，抑制了T(H)17驱动的自身免疫发展。HF与谷氨酰基-脯氨酰基tRNA合成酶(EPRS)结合，抑制了脯氨酰tRNA合成酶活性；这一抑制作用可通过外源脯氨酸或EPRS的添加而被逆转[1]。