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GC-072是一种效力强大的4-oxoquinolizine类抗生素,具备选择性抑制细菌拓扑异构酶的能力。GC-072能够在体外对B. pseudomallei的敏感和耐药菌株展示效果,也能抑制Burkholderia mallei、Bacillus anthracis、Yersinia pestis和Francisella tularensis等危险病原体。在模拟小鼠类鼻疽感染的模型中,口服GC-072表现出剂量依赖性的生存优势,显示出其作为类鼻疽口服一线治疗方案的潜力。
GC-072是一种效力强大的4-oxoquinolizine类抗生素,具备选择性抑制细菌拓扑异构酶的能力。GC-072能够在体外对B. pseudomallei的敏感和耐药菌株展示效果,也能抑制Burkholderia mallei、Bacillus anthracis、Yersinia pestis和Francisella tularensis等危险病原体。在模拟小鼠类鼻疽感染的模型中,口服GC-072表现出剂量依赖性的生存优势,显示出其作为类鼻疽口服一线治疗方案的潜力。
产品描述 | GC-072 is a potent 4-oxoquinolizine antibiotic that selectively inhibits bacterial topoisomerase. It shows in vitro activity against both sensitive and resistant strains of B. pseudomallei, and it is also effective against other dangerous pathogens such as Burkholderia mallei, Bacillus anthracis, Yersinia pestis, and Francisella tularensis. In a murine model of melioidosis, oral administration of GC-072 demonstrated dose-dependent survival benefits, indicating its potential as a first-line oral treatment option for melioidosis. |
别名 | GC072, GC 072 |
分子量 | 370.35 |
分子式 | C20H16F2N2O3 |
CAS No. | 1371629-36-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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