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顶部产品介绍化学信息储存和溶解信息计算器技术支持

TDGF1/Cripto Protein, Human, Recombinant (His)

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SPR兼容缓冲液
货号 TMPK-00073

别名 TDGF1, Cripto, CRGF, CR

TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.

TDGF1/Cripto Protein, Human, Recombinant (His)
其他形式的 “TDGF1/Cripto Protein, Human, Recombinant (His)”:
CD55/DAF Protein, Cynomolgus, Recombinant (His)
CD55/DAF Protein, Human, Recombinant (hFc)
CD55/DAF Protein, Human, Recombinant (His)
Cripto Protein, Human, Recombinant (His)
Cripto Protein, Human, Recombinant (hFc)

TDGF1/Cripto Protein, Human, Recombinant (His)

一键复制产品信息
Rating icon 还可以
SPR兼容缓冲液
货号 TMPK-00073 别名 TDGF1, Cripto, CRGF, CR

TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.

规格价格库存数量
5 μg
¥ 313
6-8日内发货
10 μg
¥ 498
6-8日内发货
20 μg
¥ 793
5日内发货
50 μg
¥ 1,580
5日内发货
100 μg
¥ 2,660
5日内发货
200 μg
¥ 4,790
5日内发货
500 μg
¥ 10,600
5日内发货
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产品介绍

生物活性
产品描述
TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
生物活性
Human ACVR1B, hFc Tag captured on CM5 Chip via Protein A can bind Human TDGF1, His Tag with an affinity constant of 0.16 μM as determined in SPR assay (Biacore T200).
研究背景
TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
种属
Human
表达系统
HEK293 Cells
标签C-His
蛋白编号P13385
蛋白构建Leu31-Thr172
蛋白纯度
> 95% as determined by Tris-Bis PAGE
蛋白性状Lyophilized powder
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名TDGF1, Cripto, CRGF, CR
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量16.92 kDa (predicted). Due to glycosylation, the protein migrates to 23-30 kDa based on Tris-Bis PAGE result.
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

计算器

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剂量转换

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技术支持

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关键词

TDGF-1TDGF 1
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