KCNMA1 Protein, Human, Recombinant

KCNMA1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q12791.

规格	价格/CNY		数量
20 μg	￥ 3,280	20日内发货
100 μg	￥ 5,300	20日内发货
1 mg	￥ 15,600	20日内发货

规格

价格/CNY

货期

数量

20 μg

￥ 3,280

20日内发货

100 μg

￥ 5,300

20日内发货

1 mg

￥ 15,600

20日内发货

产品描述	KCNMA1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q12791.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	Q12791
别名	K(VCA)alpha, Calcium-activated potassium channel subunit alpha-1, Slo1, KCNMA1, BKCA alpha, BK channel, Calcium-activated potassium channel, subfamily M subunit alpha-1, KCa1.1, Maxi K channel, Slo-alpha, Slowpoke homolog
氨基酸序列	VVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIA
蛋白构建	411-560 aa
蛋白纯度	> 85% as determined by SDS-PAGE.
分子量	17.2 kDa (predicted)

缓冲液	Tris-based buffer, 50% glycerol
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

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KCNMA1 Protein, Human, Recombinant

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