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IDH1/2-IN-1 (Compound 6b) 作为一种针对IDH1(R132H)/IDH2(R140Q)的双重抑制剂,展现了显著的效果,其IC50值为0.22 μM和1.6 μM.该化合物可以抑制癌细胞的增殖,激活抗氧化酶,并增强机体防御能力,从而有效抑制肿瘤生长.此外,IDH1/2-IN-1 还可减轻炎症反应,促进细胞凋亡(apoptosis),显示出优异的抗癌活性.此化合物主要应用于白血病的研究领域.
IDH1/2-IN-1 (Compound 6b) 作为一种针对IDH1(R132H)/IDH2(R140Q)的双重抑制剂,展现了显著的效果,其IC50值为0.22 μM和1.6 μM.该化合物可以抑制癌细胞的增殖,激活抗氧化酶,并增强机体防御能力,从而有效抑制肿瘤生长.此外,IDH1/2-IN-1 还可减轻炎症反应,促进细胞凋亡(apoptosis),显示出优异的抗癌活性.此化合物主要应用于白血病的研究领域.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research. |
体外活性 | Compound 6b (IDH1/2-IN-1) 在 THP1 和 Kasumi 白血病癌细胞中显示出显著的抗肿瘤效果,其 IC 50 值分别为 10.7 μM 和 10 μM. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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