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HCN Channel

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. HCN channels are sometimes referred to as pacemaker channels because they help to generate rhythmic activity within groups of heart and brain cells. HCN channels are activated by membrane hyperpolarization, are permeable to Na+ and K+, and are constitutively open at voltages near the resting membrane potential.[2] HCN channels are encoded by four genes (HCN1, 2, 3, 4) and are widely expressed throughout the heart and the central nervous system.

ZD7288
T7516133059-99-1
ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂,可抑制海马突触可塑性。
  • ¥ 497
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Zatebradine hydrochloride
T13387L91940-87-3
Zatebradine hydrochloride (UL-FS-49CL) 是一种高效的 、有效的HCN Channel 抑制剂( IC50 :1.96 µM)。 HCN Channel 是一种有效的超极化激活环核苷酸门控通道。 Zatebradine hydrochloride 阻止通过人类 HCN1,HCN2,HCN3 和 HCN4 通道的缓慢内向电流,其 IC50 值分别为 1.83 µM,2.21 µM,1.90 µM 和 1.88 µM。
  • ¥ 187
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Alinidine
T8398033178-86-8In house
Alinidine 是一种 HCN 通道阻断剂,具有抗心律失常作用,可用于研究心绞痛。
  • ¥ 1300
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Ivabradine hydrochloride
T2535148849-67-6
Ivabradine hydrochloride (S 16257-2) 是一种可口服的,超极化激活的环核苷酸门控离子通道通道阻滞剂。
  • ¥ 280
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Cilobradine hydrochloride
T10813186097-54-1
Cilobradine hydrochloride (DK-AH 269) 是一种 HCN 通道阻断剂。
  • ¥ 198
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