Penconazole is a typical triazole fungicide, which mainly used to control powdery mildew in apples, grapes, and vegetables. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats [1] [2].

Penconazole (67 mg/kg; i.p.; every 2 days during 9 days) induces oxidative stress in rat cerebrum and cerebellum tissues [2]. Penconazole has the ability to induce oxidative damage in the brain of adult rats, as evidenced by an increase of lipid peroxidation and protein oxidation besides the perturbations in the enzymatic and nonenzymatic antioxidant status. Penconazole also affects the cholinergic system, activities of membrane-bound ATPases, and brain histoarchitecture. Penconazole is a potential neurotoxicant pesticide that exerts its neurotoxic effects via the generation of oxidative stress. Penconazole causes a significant inhibition of AChE activity in the cerebrum (11%) and cerebellum (25%) of adult rats [2]. Animal Model: Twelve male Wistar rats [2] Dosage: 67 mg/kg Administration: I.p.; every 2 days during 9 days Result: A significant increase was obtained in the absolute and relative weights of the cerebrum and cerebellum, respectively.