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ICOS Protein, Mouse, Recombinant (hFc)
产品编号 TMPY-02473
ICOS Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is Q9WVS0.
ICOS Protein, Mouse, Recombinant (hFc)
产品编号 TMPY-02473
ICOS Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is Q9WVS0.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μg | ¥ 3,820 | 现货 | |
| 200 μg | ¥ 6,750 | 5日内发货 | |
| 500 μg | ¥ 14,280 | 5日内发货 |
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产品信息
| 生物活性 | Immobilized Recombinant Mouse ICOS Ligand / B7-H2 / ICOSLG Protein (His Tag) at 2 μg/ml (100 μl/well) can bind Recombinant Mouse ICOS / AILIM / CD278 Protein (Fc Tag), the EC50 is 100-300 ng/mL.  |
| 产品描述 | ICOS Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is Q9WVS0. |
| 种属 | Mouse |
| 表达系统 | HEK293 Cells |
| 标签 | C-hFc |
| 蛋白编号 | Q9WVS0 |
| 别名 | Ly115,inducible T-cell co-stimulator,H4,CRP-1,CCLP,AILIM |
| 蛋白构建 | A DNA sequence encoding the mouse ICOS (Q9WVS0) extracellular domain (Met 1-Leu 142) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Glu 21 |
| 蛋白纯度 | > 95 % as determined by SDS-PAGE  |
| 分子量 | 40.9 kDa (predicted) |
| 内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| 复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| 存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. |
| 研究背景 | Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4, and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which are essential for the germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. Also, ICOS is more potent in the induction of IL-10 production, a cytokine important for the suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provide key second signals that can regulate the activation, inhibition, and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested as being involved in the development of airway inflammation and airway hyperresponsiveness.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
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