Name: Dp44mT
Brand: TargetMol
SKU: T6821
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 145

现货

5 mg

¥ 297

现货

10 mg

¥ 493

现货

25 mg

¥ 978

现货

50 mg

¥ 1,560

现货

100 mg

¥ 2,430

现货

200 mg

¥ 3,620

现货

1 mL x 10 mM (in DMSO)

¥ 338

现货

产品介绍

生物活性

产品描述	Dp44mT, a effective iron chelator, has selective antitumor activity.
体外活性	在MDA-MB-231细胞中，Dp44mT选择性地靶向拓扑异构酶topo2α，造成DNA损伤。Dp44mT对SK-N-MC、SK-Mel-28和MCF-7细胞表现出显著的抗增殖效果，其IC50分别为30 nM、60 nM和60 nM，而对正常的MRC-5成纤维细胞无影响。在SK-N-MC神经上皮瘤和M109细胞中，Dp44mT抑制了细胞从Fe-Tf的铁摄取，并诱导细胞凋亡。作为Pgp底物的Dp44mT，还通过劫持溶酶体P糖蛋白（Pgp）克服了多药耐药性。
体内活性	Dp44mT（0.4 mg/kg，静脉注射）通过剂量依赖方式抑制CD2F1小鼠体内植入的M109肿瘤。
细胞实验	SK-N-MC, SK-Mel-28, MCF-7 and MRC-5 cells are incubated in the presence and absence of DFO, 311, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, doxorubicin, and the DpT series of chelators (0-25 μM) for 72 hours at 37°C. The effect of the chelators on proliferation is examined using the MTT assay.
动物实验	CD2F1 mice that are implanted M109 tumors intravenous inject Dp44mT (dissolved in Propylene glycol) 4 mg/kg in twice daily.
别名	2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 16.67 mg/mL (58.42 mM), Sonication is recommended.

Ethanol: 47 mg/mL (164.7 mM), Sonication is recommended.

H2O: Insoluble

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.01 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol