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Compound 48/80 trihydrochloride

Name: Compound 48/80 trihydrochloride
Brand: TargetMol
SKU: T13623
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

产品编号 T13623Cas号 848035-21-2

别名 C48/80 trihydrochloride

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。

Compound 48/80 trihydrochloride

纯度: 98%

产品编号 T13623 别名 C48/80 trihydrochlorideCas号 848035-21-2

规格	价格	库存	数量
1 mg	¥ 148	现货
2 mg	¥ 172	现货

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纯度:98%

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凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务.

产品介绍

生物活性

产品描述	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and histamine releaser. Compound 48/80 trihydrochloride inhibits phosphatidylinositol-specific phospholipase C activity in human platelets.
体外活性	Compound 48/80 trihydrochloride inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with similar efficiency (IC50s: 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction)). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80 [1].
体内活性	Compound 48/80 trihydrochloride causes oxidative stress in the rat adrenal gland through mast cell degranulation. Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3, or 6 h) increases serum serotonin, histamine, and corticosterone levels at 0.5 h, but their increases were reduced thereafter [3].
别名	C48/80 trihydrochloride

化学信息

分子量	629.1
分子式	C₃₂H₄₈Cl₃N₃O₃
CAS No.	848035-21-2

储存&溶解度

存储

keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 12.58 mg/mL (20 mM), Sonication is recommended.

DMSO: 6.29 mg/mL (10 mM), Sonication is recommended.

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.5896 mL	7.9479 mL	15.8957 mL	79.4786 mL
5 mM	0.3179 mL	1.5896 mL	3.1791 mL	15.8957 mL
10 mM	0.1590 mL	0.7948 mL	1.5896 mL	7.9479 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0795 mL	0.3974 mL	0.7948 mL	3.9739 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLddH2O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Compound 48/80Compound 48/80 TrihydrochlorideC48/80 TrihydrochlorideC48/80

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Compound 48/80 trihydrochloride

Compound 48/80 trihydrochloride

与"Compound 48/80 trihydrochloride"相关的抑制剂

产品介绍

计算器

体内实验配液计算器

剂量转换

关键词