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Nicotredole (Tryptamide) 是一种口服有效的消炎剂,与 Phenylbutazone 的抗炎作用相当。它仅具有弱的致溃疡活性。它可用于缓解疼痛方面的研究。
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Nicotredole (Tryptamide) 是一种口服有效的消炎剂,与 Phenylbutazone 的抗炎作用相当。它仅具有弱的致溃疡活性。它可用于缓解疼痛方面的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 173 | 现货 | |
2 mg | ¥ 245 | 现货 | |
5 mg | ¥ 397 | 现货 | |
10 mg | ¥ 596 | 现货 | |
25 mg | ¥ 980 | 现货 | |
50 mg | ¥ 1,480 | 现货 | |
100 mg | ¥ 2,190 | 现货 | |
200 mg | ¥ 2,970 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 496 | 现货 |
产品描述 | Nicotredole (Tryptamide) (Tryptamide) is an orally active analgesic and anti-inflammatory agent. Nicotredole exhibits evident anti-inflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity. |
体外活性 | Nicotredole inhibits prostaglandin synthetase activity in vitro assay[1]. |
体内活性 | Nicotredole displays antiinflammatory effects in carrageenin-induced rat paw oedema [1] . Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice [1] . Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively [1] . Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively [1] . Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t 1/2 =4.92-17.5 min) and elimination (t 1/2 =55.72-74.52 min), can reach C max (11-13 μg/cm 3 ) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg•h/cm 3 ) [2] . |
别名 | 尼可曲朵, 尼可曲多;尼可曲朵, Tryptamide |
分子量 | 265.31 |
分子式 | C16H15N3O |
CAS No. | 29876-14-0 |
Smiles | O=C(NCCc1c[nH]c2ccccc12)c1cccnc1 |
密度 | 1.247g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 25 mg/mL (94.23 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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