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D-3263 is an agonist of transient receptor potential melatonin member 8 (TRPM8) with potential antitumor activity.
D-3263 is an agonist of transient receptor potential melatonin member 8 (TRPM8) with potential antitumor activity.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 11,700 | 1-2周 | |
50 mg | ¥ 15,300 | 1-2周 | |
100 mg | ¥ 19,500 | 1-2周 |
产品描述 | D-3263 is an agonist of transient receptor potential melatonin member 8 (TRPM8) with potential antitumor activity. |
体外活性 | D-3263 induces calcium flux and cell death in cells expressing TRPM8 in vitro. |
体内活性 | D-3263 alone (50 or 100 mg / kg / d) or in combination with finasteride (10 mg / kg / d) can lead to decreased prostate hyperplasia in rats, with evidence of dose response. The highest dose of TRPM8 agonist D-3263 combined with finasteride caused lower prostate weight than the highest dose of D-3263 or finasteride alone, indicating a potential additive effect. |
分子量 | 373.49 |
分子式 | C21H31N3O3 |
CAS No. | 947257-66-1 |
密度 | 1.137 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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