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Satraplatin (BMS182751) 是一种烷化剂 ,是一种口服的抗肿瘤铂 (IV) 复合物,具有广泛的抗肿瘤效果。
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Satraplatin (BMS182751) 是一种烷化剂 ,是一种口服的抗肿瘤铂 (IV) 复合物,具有广泛的抗肿瘤效果。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 953 | 现货 | |
2 mg | ¥ 1,390 | 现货 | |
5 mg | ¥ 2,320 | 现货 | |
10 mg | ¥ 3,290 | 现货 | |
25 mg | ¥ 5,280 | 现货 | |
50 mg | ¥ 7,190 | 现货 | |
100 mg | ¥ 9,730 | 现货 |
产品描述 | Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies. |
体外活性 | KB-R 细胞对 satraplatin 没有表现出交叉耐药性。几乎所有转运蛋白的表达状态在 KB-R 细胞中被上调。KB 与 KB-R 细胞之间的 GSH 水平没有差异。流式细胞术分析表明,satraplatin 可以在 KB-R 细胞中引起 G2/M 阶段的阻滞。KB-R 细胞含有富集的侧群细胞[1]。 |
细胞实验 | CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment[1]. |
别名 | 顺式-二氯-反式-二乙酸-氨-环己胺合铂, 沙铂, JM216, BMY45594, BMS182751 |
分子量 | 500.28 |
分子式 | C10H22Cl2N2O4Pt |
CAS No. | 129580-63-8 |
Smiles | [Pt+4]([NH2]C1CCCCC1)([O-]C(C)=O)([O-]C(C)=O)([Cl-])([Cl-])[NH3] |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 33 mg/mL (65.96 mM), DMSO inactivates the activity of Satraplatin. | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
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