NCAM2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is O15394-1.

Human

HEK293 Cells

neural cell adhesion molecule 2,NCAM21

A DNA sequence encoding the human NCAM2 (NP_004531.2) (Met1-Asn697) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Leu 20

> 95 % as determined by SDS-PAGE

A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

NCAM2 is a member of the immunoglobulin superfamily of cell adhesion molecules (IgCAMs). The neural cell adhesion molecule 2 (NCAM2) is encoded by a gene on chromosome 21 in humans. Neural cell adhesion molecules 2 (NCAM2/OCAM/RNCAM), is a paralog of NCAM1. The protein exists in transmembrane and a lipid-anchored isoform and has an ectodomain consisting of five immunoglobulin modules and two fibronectin type 3 homology modules. Structural models of the NCAM2 ectodomain reveal that it facilitates cell adhesion through reciprocal interactions between the membrane-distal immunoglobulin modules.NCAM (Neural Cell Adhesion Molecule) proteins are involved in axonal migration, synaptic formation, and plasticity. Poor axonal growth and fasciculation are observed in animal models deficient for NCAM2.