K145

Name: K145
Brand: TargetMol
SKU: T11739
Price: 197 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T11739Cas号 1309444-75-4

K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM.

K145

还可以

产品编号 T11739Cas号 1309444-75-4

规格	价格	库存
25 mg	¥ 11,700	1-2周
50 mg	¥ 15,300	1-2周
100 mg	¥ 19,500	1-2周

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产品介绍

生物活性

产品描述	K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM.
靶点活性	SPHK2:(ki)6.4 µM , SPHK2:4.3 µM
体外活性	K145 (10 μM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells. K145 (4-8 μM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt. Treatment with K145 (10 μM) causes a decrease of total cellular S1P without significant effects on ceramide levels.K145 (0-10 μM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner.
体内活性	K145 treatment significantly inhibits the growth of U937 tumors in nude mice.