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14-3-3 beta Protein, Human, Recombinant

产品编号 TMPY-01273

别名: 14-3-3 β, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta, KCIP-1, HEL-S-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, β, HS1, GW128

14-3-3 beta Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 28 kDa and the accession number is P31946-1.

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14-3-3 beta Protein, Human, Recombinant

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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生物活性	Testing in progress
产品描述	14-3-3 beta Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 28 kDa and the accession number is P31946-1.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	P31946-1
别名	14-3-3 β, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta, KCIP-1, HEL-S-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, β, HS1, GW128
蛋白构建	The Human YWHAB (NP_003395.1) (Met 1-Asn 246) was expressed, with two additional amino acids (Gly & Pro) at the N-terminus.
蛋白纯度	≥ 90 % as determined by SDS-PAGE
分子量	28 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 150 mM NaCl, 0.1 mM DTT, 10% glycerol, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

参考文献

1. Tommerup N,et al.(1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50. 2. Jin YH,et al.(2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5. 3. Sekimoto T,et al.(2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.

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Keywords

14-3-3 beta Protein, Human, Recombinant 14-3-3 β HS-1 KCIP1 YWHAA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta KCIP-1 HS 1 KCIP 1 HEL-S-1 GW 128 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, β HS1 GW-128 GW128 recombinant recombinant-proteins proteins protein

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