JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autophosphorylation of FLT3 and activity of downstream signaling molecules of FLT3-D835Y and FLT3-ITD.
JH-IX-179
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产品编号 T32288 别名 JH-IX179, JH-IX 179
JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autophosphorylation of FLT3 and activity of downstream signaling molecules of FLT3-D835Y and FLT3-ITD.
JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autophosphorylation of FLT3 and activity of downstream signaling molecules of FLT3-D835Y and FLT3-ITD.
别名
JH-IX179, JH-IX 179
化学信息
分子量
436.52
分子式
C26H24N6O
密度
no data available
储存&溶解度
存储
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
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