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Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素,可减少尿液中钠丢失量,也用于增加血压,有用于阿狄森氏病的研究潜力。
Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素,可减少尿液中钠丢失量,也用于增加血压,有用于阿狄森氏病的研究潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 mg | ¥ 247 | 现货 | |
200 mg | ¥ 338 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 272 | 现货 |
产品描述 | Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. |
别名 | 醋酸氟氢可的松, 9α-fluorocortisol acetate, 9α-Fluorcortisol acetate, 9α-Fludrocortisone acetate |
分子量 | 422.49 |
分子式 | C23H31FO6 |
CAS No. | 514-36-3 |
Smiles | [H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)CC(=O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C |
密度 | 1.3 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 45 mg/mL (106.51 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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