Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.

别名

9α-Fluorcortisol acetate, 9α-Fludrocortisone acetate, 醋酸氟氢可的松, 9α-fluorocortisol acetate

化学信息

分子量	422.49
分子式	C₂₃H₃₁FO₆
CAS No.	514-36-3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 45 mg/mL (106.51 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3669 mL	11.8346 mL	23.6692 mL	118.3460 mL
5 mM	0.4734 mL	2.3669 mL	4.7338 mL	23.6692 mL
10 mM	0.2367 mL	1.1835 mL	2.3669 mL	11.8346 mL
20 mM	0.1183 mL	0.5917 mL	1.1835 mL	5.9173 mL
50 mM	0.0473 mL	0.2367 mL	0.4734 mL	2.3669 mL
100 mM	0.0237 mL	0.1183 mL	0.2367 mL	1.1835 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLddH2O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

FludrocortisoneAutophagyFludrocortisone Acetate9alpha-fluorocortisol AcetateFludrocortisone acetateInhibitor9alpha-Fludrocortisone Acetate9a-fluorocortisol Acetate9α-Fludrocortisone Acetate9α-Fluorcortisol Acetate9α-Fludrocortisone9a-Fluorcortisol Acetate9α-FluorcortisolinhibitMineralocorticoid Receptor9a-Fludrocortisone Acetate9α-fluorocortisol Acetate9alpha-Fluorcortisol Acetate

Fludrocortisone acetate

Fludrocortisone acetate

与"Fludrocortisone acetate"相关的抑制剂

"Fludrocortisone acetate"的相关化合物库

产品介绍

计算器

体内实验配液计算器

剂量转换

关键词