HIF-1α-IN-5

Name: HIF-1α-IN-5
Brand: TargetMol
SKU: T60532
Rating: 4.5 (1 reviews)

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产品编号 T60532

HIF-1α-IN-5 是 HIF-1α的抑制剂，在 HEK293T 细胞中的 IC50值为 24 nM，也可抑制 MAO-A 的活性。在缺氧条件下， HIF-1α-IN-5可下调 VEGF 和 PDK1 mRNA 的表达。HIF-1α-IN-5 具有用于癌症研究的潜力。

HIF-1α-IN-5

还可以

产品编号 T60532

规格	价格	库存
25 mg	¥ 10,600	10-14周
50 mg	¥ 13,800	10-14周
100 mg	¥ 17,500	10-14周

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产品介绍

生物活性

产品描述

HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A. HIF-1α-IN-5 downregulates the mRNA expressions of VEGF and PDK1 under hypoxia. HIF-1α-IN-5 has the potential to be used in the cancer research[1].

体外活性

HIF-1α-IN-5 (compound 15, 24 h) shows inhibitory effects against HIF-1α transcription in HEK293T cells, with an IC 50 value of 24 nM [1]. HIF-1α-IN-5 (0-50 μM, 24 h) downregulates VEGF and PDK1 mRNA expressions under hypoxia in HEK293T cells [1]. HIF-1α-IN-5 (10 μM) inhibits MAO-A activity activity by 80.64%, and ADORA2A by 43.95% [1]. RT-PCR [1] Cell Line: HEK293T cells under hypoxia Concentration: 0-50 μM approximately Incubation Time: 24 h Result: Dose-dependently reduces VEGF and PDK1 mRNA expression.