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IL-17A Protein, Mouse, Recombinant

产品编号 TMPY-02900
IL-17A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.5 kDa and the accession number is Q62386.
规格价格库存数量
20 μg¥ 2,260现货
100 μg¥ 4,4305日内发货
200 μg¥ 7,8505日内发货
500 μg¥ 16,6705日内发货
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产品信息

生物活性
1. Measured by its binding ability in a functional ELISA. Immobilized mouse Il17A at 2 μg/mL (100 μl/well) can bind mouse IL17RA-His , The EC50 of mouse IL17RA-His is 12-45 ng/mL. 2. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells in the presense of 20 ng/mL TNFα. The ED50 for this effect is 0.15-0.6 ng/mL.
IL-17A Protein, Mouse, RecombinantIL-17A Protein, Mouse, Recombinant
产品描述
IL-17A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.5 kDa and the accession number is Q62386.
种属
Mouse
表达系统
E. coli
标签Tag Free
蛋白编号Q62386
别名
白细胞介素,白介素,interleukin 17A,IL-17A,IL-17,Il17,Ctla-8,Ctla8
蛋白构建
A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr22-Ala158) was expressed with a N-terminal Met. Predicted N terminal: Met
蛋白纯度
> 97 % as determined by SDS-PAGE
IL-17A Protein, Mouse, Recombinant
分子量15.5 kDa (predicted); 16 kDa (reducing conditions)
内毒素Please contact us for more information.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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