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CDK12-IN-5 是一种高效的 CDK12 抑制剂,具有潜在的抗癌抗肿瘤活性,可口用于研究乳腺癌和卵巢癌。
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CDK12-IN-5 是一种高效的 CDK12 抑制剂,具有潜在的抗癌抗肿瘤活性,可口用于研究乳腺癌和卵巢癌。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,690 | 现货 | |
5 mg | ¥ 4,230 | 现货 | |
10 mg | ¥ 5,880 | 现货 | |
25 mg | ¥ 8,880 | 现货 | |
50 mg | ¥ 11,800 | 现货 | |
100 mg | ¥ 16,200 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 4,650 | 现货 |
产品描述 | CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer. |
靶点活性 | CDK12:23.9 nM, CDK2-CyclinE:173 μM, CDK9-cyclinT1:127 μM |
体外活性 | CDK12-IN-5 能抑制 MDA - MB - 231 细胞 BRCA1 mRNA 表达,在 MDA - MB - 231 细胞( IC50=4.19 n M )和 CAL-120 细胞( IC50=3.57 n M )中具有抗增殖活性[1]。 |
分子量 | 454.36 |
分子式 | C18H15F5N8O |
CAS No. | 2651200-35-8 |
Smiles | FC=1C=CC=2N=C(NC2C1F)CNC3=NC(=NC4=C(C=NN34)C(F)(F)F)N5CCOCC5 |
密度 | 1.77 g/cm3 (Predicted) |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 100 mg/mL (220.09 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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