Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells.

首次从冲绳海绵Theonella swinhoei中分离出的Swinholide A能够使actin[1]二聚体化。Swinholide A从Theonella swinhoei海绵中分离得到，对多种癌细胞系具有高度细胞毒性[2]。Swinholide A在体外实验中，不论在聚合或非聚合缓冲液中，均能够扰乱细胞内的actin细胞骨架，通过与actin二聚体形成一种Swinholide A分子对应一个actin二聚体的结合配比，从而封存actin二聚体。另外，它还能够在体外快速且高度协同地断裂F-actin[2]。