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PBE-AMF是一种具有抗癌活性的前药,能够活化H2O2.它通过抑制DNA合成、降低ATP水平、诱导细胞凋亡(apoptosis)及阻碍细胞周期来抑制肿瘤细胞增殖.此化合物在抑制MDA-MB-231细胞增殖方面表现出高效性和选择性(IC50=6.4 μM),同时对非癌性MCF-10A细胞具有较低的毒性影响.
PBE-AMF是一种具有抗癌活性的前药,能够活化H2O2.它通过抑制DNA合成、降低ATP水平、诱导细胞凋亡(apoptosis)及阻碍细胞周期来抑制肿瘤细胞增殖.此化合物在抑制MDA-MB-231细胞增殖方面表现出高效性和选择性(IC50=6.4 μM),同时对非癌性MCF-10A细胞具有较低的毒性影响.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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