OTAVAchemicals offers Enhancer of Zeste Homolog 2 (EZH2) Targeted Library. It contains 979 compounds with predicted inhibitory activity against this enzyme.
Life Chemicals has designed a Library of over 3,900 drug-like screening compounds that are small-molecule analogs of known ligase inhibitors with experimentally determined activity.
The Life Chemicals Receptor-based Screening Library contains over 2,000 potential lysine-specific demethylase 4A (KDM4A) inhibitors selected with computational chemistry and virtual screening techniques. The Library presented is a rich source of inhibitors for screening projects in KDM-related drug discovery.
OTAVAchemicals offers a Lysine-specific demethylase 4C (GASC1) Targeted Library. It contains 966 compounds with predicted inhibitory activity against this enzyme.
ChemDiv 的Aurora A-B Kinases 库包含10,000种化合物。 Aurora 激酶是一类丝氨酸 苏氨酸激酶家族,包括Aurora A (AURKA)、Aurora B (AURKB)和Aurora C (AURKC)。它们对细胞分裂至关重要,通过调节有丝分裂特别是染色体分离过程来实现。除了调节有丝分裂,Aurora 激酶还参与调节减数分裂。
OTAVAchemicals DOT1L Targeted Library (622 compounds) has been carefully designed with a receptor-based approach that included docking of Drug-like Green Collection in the active site of human DOT1L (crystal structure of the complex with inhibitor FED2, PDB ID 4EQZ)