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PI3Kα-IN-21(化合物8)是一种高度选择性的PI3Kα抑制剂,其对PI3Kα的抑制选择性分别是PI3Kβ、PI3Kγ和PI3Kδ的10.41倍、16.99倍和37.53倍(IC50分别为96.89、568.24和397.48 nM).该化合物能够抑制癌细胞的活性、增殖和迁移,并通过激活PI3K/Akt/mTOR信号通路促使线粒体走向凋亡.在非小细胞肺癌的小鼠模型中,PI3Kα-IN-21展现出显著的抗肿瘤活性.
PI3Kα-IN-21(化合物8)是一种高度选择性的PI3Kα抑制剂,其对PI3Kα的抑制选择性分别是PI3Kβ、PI3Kγ和PI3Kδ的10.41倍、16.99倍和37.53倍(IC50分别为96.89、568.24和397.48 nM).该化合物能够抑制癌细胞的活性、增殖和迁移,并通过激活PI3K/Akt/mTOR信号通路促使线粒体走向凋亡.在非小细胞肺癌的小鼠模型中,PI3Kα-IN-21展现出显著的抗肿瘤活性.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | PI3Kα-IN-21 (compound 8) is a selective inhibitor of PI3Kα, demonstrating greater selectivity over PI3Kβ, PI3Kγ, and PI3Kδ by factors of 10.41, 16.99, and 37.53 respectively (IC50: 96.89/568.24/397.48 nM). This compound inhibits cancer cell activity, proliferation, and migration while inducing mitochondrial apoptosis through the PI3K/Akt/mTOR pathway. Additionally, PI3Kα-IN-21 has shown in vivo antitumor efficacy in a mouse model of non-small cell lung cancer. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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