Nucleophosmin Protein, Human, Recombinant (His)

产品编号 TMPY-01925

Nucleophosmin Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P06748-1.

Nucleophosmin Protein, Human, Recombinant (His)

产品编号 TMPY-01925

Nucleophosmin Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P06748-1.

规格	价格	库存	数量
100 μg	¥ 3,820	5日内发货

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产品信息

生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	Nucleophosmin Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P06748-1.
种属	Human
表达系统	E. coli
标签	N-His
蛋白编号	P06748-1
别名	nucleophosmin (nucleolar phosphoprotein B23, numatrin),NPM,B23
蛋白构建	A DNA sequence encoding the human NPM1 isoform 1 (P06748-1) N-terminal segment (Met 9-Leu 158) was expressed, with a polyhistide tag at the N-terminus. Predicted N terminal: Met
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	17.8 kDa (predicted); 20 kDa (reducing conditions)
内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 6. 0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23 or numatrin, is a member of the nucleoplasmin family. Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication, and regulation of p53. The NPM1 gene is frequently involved in chromosomal translocation, mutation, and deletion. Mutations of the NPM1 gene leading to the expression of a cytoplasmic mutant protein, NPMc+, are the most frequent genetic abnormalities found in acute myeloid leukemias. Acute myeloid leukemia (AML) with mutated NPM1 have distinct characteristics, including a significant association with a normal karyotype, the involvement of different hematopoietic lineages, a specific gene-expression profile, and clinically, a better response to induction therapy, and a favorable prognosis. Also, NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged, and deleted in human cancer. Traditionally regarded as a tumor marker and a putative proto-oncogene, it has now also been attributed with tumor-suppressor functions.