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FK-453 是一种有效的非黄嘌呤腺苷 A1 受体拮抗剂,具有利尿和肾血管扩张活性。
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FK-453 是一种有效的非黄嘌呤腺苷 A1 受体拮抗剂,具有利尿和肾血管扩张活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,730 | 现货 | |
5 mg | ¥ 4,330 | 现货 | |
10 mg | ¥ 6,180 | 现货 | |
25 mg | ¥ 9,370 | 现货 | |
50 mg | ¥ 12,600 | 现货 | |
100 mg | ¥ 16,800 | 现货 | |
500 mg | ¥ 33,900 | 现货 |
产品描述 | FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity. |
体内活性 | FK-453 (50, 100, and 200 mg; three single oral) Glomerular filtration rate (clearance of 51Cr-labeled EDTA) rose by 18.0%, 3 h after the administration of 100 mg of FK-453 and by 18.3% and 23.5%, 2 and 3 h, respectively, after the 200 mg dose. There were statistically significant increases in urine flow rate and osmolar clearance, as well as absolute and fractional excretions of sodium, phosphate, bicarbonate, chloride, magnesium, and uric acid in response to FK-453.[2] |
别名 | FK453, FK 453 |
分子量 | 375.46 |
分子式 | C23H25N3O2 |
CAS No. | 121524-18-3 |
Smiles | C(=C/C(=O)N1[C@@H](CCO)CCCC1)\C=2C(=NN3C2C=CC=C3)C4=CC=CC=C4 |
密度 | 1.21g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 60 mg/mL (159.8 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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