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DFX117作为一种口服有效的PI3Kα和c-Met酪氨酸激酶(c-Met)选择性抑制剂,通过抑制PI3K/Akt/mTOR通路发挥作用.它能够抑制NCI-H1975、NCI-H1993和HCC827细胞系的增殖,具有0.02-0.08 µM的IC50.此外,DFX117还可在G0/G1期阻滞细胞周期,并在A549与NCI-H1975细胞中诱导细胞凋亡(apoptosis).在小鼠模型中,DFX117展示了显著的抗肿瘤活性.
DFX117作为一种口服有效的PI3Kα和c-Met酪氨酸激酶(c-Met)选择性抑制剂,通过抑制PI3K/Akt/mTOR通路发挥作用.它能够抑制NCI-H1975、NCI-H1993和HCC827细胞系的增殖,具有0.02-0.08 µM的IC50.此外,DFX117还可在G0/G1期阻滞细胞周期,并在A549与NCI-H1975细胞中诱导细胞凋亡(apoptosis).在小鼠模型中,DFX117展示了显著的抗肿瘤活性.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | DFX117 is an orally effective selective inhibitor of PI3Kα and c-Met tyrosine kinase (c-Met). This compound inhibits the PI3K/Akt/mTOR pathway and suppresses the proliferation of NCI-H1975, NCI-H1993, and HCC827 cells, with IC50 values ranging from 0.02 to 0.08 µM. Additionally, DFX117 induces cell cycle arrest in the G0/G1 phase and triggers apoptosis (apoptosis) in A549 and NCI-H1975 cells. It also exhibits antitumor activity in mice. |
分子量 | 572.58 |
分子式 | C26H26F2N6O5S |
CAS No. | 2125500-60-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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