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BCMA/TNFRSF17 Protein, Human, Recombinant, AF488-Labeled

产品编号 TMPY-07023

BCMA/TNFRSF17 Protein, Human, Recombinant, AF488-Labeled is expressed in HEK293 Cells. The accession number is Q02223-1.

BCMA/TNFRSF17 Protein, Human, Recombinant, AF488-Labeled

BCMA/TNFRSF17 Protein, Human, Recombinant, AF488-Labeled

产品编号 TMPY-07023
BCMA/TNFRSF17 Protein, Human, Recombinant, AF488-Labeled is expressed in HEK293 Cells. The accession number is Q02223-1.
规格价格库存数量
25 μg
¥ 3,430
期货
100 μg
¥ 10,900
期货
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产品信息

生物活性
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述
BCMA/TNFRSF17 Protein, Human, Recombinant, AF488-Labeled is expressed in HEK293 Cells. The accession number is Q02223-1.
种属
Human
表达系统
HEK293 Cells
标签C-His
蛋白编号Q02223-1
别名
TNFRSF13A,CD269,BCMA,BCM
蛋白构建
A DNA sequence encoding the extracellular domain (Met1-Ala54) of human TNFRSF17 (NP_001183.2) was expressed with a C-terminal polyhistidine tag. The protein is site-specifically conjugated with AF 488 (Excitation Max.= 495 nm, Emission Max.= 519 nm).
蛋白纯度
≥ 90% as determined by SDS-PAGE.
分子量11.8 kDa (predicted)
内毒素< 1.0 EU per μg protein as determined by the LAL method.
缓冲液This product is Lyophilized from sterile PBS, pH 7.4, with 5 %-8 % trehalose. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
复溶方法
Please refer to the lot-specific COA.
存储
Twelve months from date of receipt at -20℃ to -70℃ in lyophilized form and 3 months at -70℃ under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

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