hMAO-B-IN-9

Name: hMAO-B-IN-9
Brand: TargetMol
SKU: T89331
Price: 99 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T89331

hMAO-B-IN-9(Compound 25c) 作为非竞争性单胺氧化酶 B (MAO-B) 抑制剂,展现IC50为1.58 µM (hMAO-B)的效力.此化合物与铁离子形成螯合复合物,有效抑制Erastin引发的铁死亡(ferroptosis),并通过降低活性氧(ROS)水平,发挥抗氧化作用.hMAO-B-IN-9 还能改善小鼠认知功能,同时在30 mg/kg剂量下未见明显毒性.血脑屏障的通透性经计算机模拟预测表明,该化合物具备良好的穿透能力.

hMAO-B-IN-9

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产品编号 T89331

规格	价格	库存	数量
10 mg	询价	期货
50 mg	询价	期货

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产品描述

hMAO-B-IN-9 (Compound 25c) acts as a non-competitive inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 1.58 µM (hMAO-B). Additionally, it functions as a chelator, forming complexes with iron ions which suppress ferroptosis induced by erastin. This compound exhibits antioxidant activity through the downregulation of reactive oxygen species (ROS) levels. It has also been shown to improve cognitive functions in mice without significant toxicity at a dose of 30 mg/kg. Computer predictions suggest that hMAO-B-IN-9 is permeable to the blood-brain barrier.