SR-1277

Name: SR-1277
Brand: TargetMol
SKU: T38927
Rating: 4.5 (1 reviews)

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产品编号 T38927Cas号 1446715-47-4

SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research.

SR-1277

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产品编号 T38927Cas号 1446715-47-4

规格	价格	库存	数量
25 mg	¥ 10,600	4-6周

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产品描述	SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research.
靶点活性	CKIδ:49 nM (IC50), CKIϵ:260 nM (IC50)
体外活性	SR-1277 exhibits antiproliferative effects in A375 cells, with an EC 50 of 22 nM[1].
体内活性	SR-1277 (1 mg/kg; i.v.) exhibits C max (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM?h), T 1/2 (1.42 h) and brain penetration (24%) in mice[1].