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Bz 423 是一种有效的免疫调节剂,通过激活 Bax 和 Bak 来诱导线粒体外膜通透和细胞色素 c 释放来诱导细胞凋亡。Bz 423 在狼疮小鼠模型中显示出部分活性。
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Bz 423 是一种有效的免疫调节剂,通过激活 Bax 和 Bak 来诱导线粒体外膜通透和细胞色素 c 释放来诱导细胞凋亡。Bz 423 在狼疮小鼠模型中显示出部分活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 468 | 5日内发货 | |
5 mg | ¥ 788 | 5日内发货 | |
10 mg | ¥ 1,280 | 5日内发货 | |
25 mg | ¥ 2,960 | 5日内发货 | |
50 mg | 询价 | 8-10周 | |
1 mL x 10 mM (in DMSO) | ¥ 872 | 5日内发货 |
产品描述 | Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus. |
体外活性 | Bz-423 triggers the activation of Bax and Bak without concurrently activating ASK1/JNK in Ramos cells[2]. The induction of apoptosis by Bz-423 in Ramos cells relies on superoxide, and it elicits a heightened superoxide response in these cells, resulting in the swift demise of Ramos B cells. In MEFs, Bz-423 rapidly elevates superoxide levels within 1 hour, with the extent of the increase depending on the concentration. In Ramos cells, Bz-423-induced superoxide generation instigates the activation of Bax and Bak, mediated by alterations in Mcl-1 expression and the functional activation of BH3-only proteins[1]. |
别名 | BZ48 |
分子量 | 440.92 |
分子式 | C27H21ClN2O2 |
CAS No. | 216691-95-1 |
Smiles | CN1c2ccc(Cl)cc2C(=NC(Cc2ccc3ccccc3c2)C1=O)c1ccc(O)cc1 |
密度 | 1.28 g/cm3 (Predicted) |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 80 mg/mL (181.44 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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