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Manool 是一种来自丹参的二萜,在小鼠黑色素瘤模型中显示出抗肿瘤活性。Manool 可使癌细胞细胞周期停滞在的 G(2)/M 期,降低预防染色体损伤和癌前病变。Manool 促使大鼠主动脉中由 NO/cGMP 信号通路介导的内皮依赖性血管松弛和血压降低。
Manool 是一种来自丹参的二萜,在小鼠黑色素瘤模型中显示出抗肿瘤活性。Manool 可使癌细胞细胞周期停滞在的 G(2)/M 期,降低预防染色体损伤和癌前病变。Manool 促使大鼠主动脉中由 NO/cGMP 信号通路介导的内皮依赖性血管松弛和血压降低。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 246 | 现货 | |
5 mg | ¥ 568 | 现货 | |
10 mg | 询价 | 现货 | |
25 mg | 询价 | 现货 |
产品描述 | Manool, a diterpene from Salvia miltiorrhiza, showed antitumor activity in a mouse melanoma model.Manool caused cell cycle arrest in the G(2)/M phase of cancer cells, reducing the prevention of chromosomal damage and precancerous lesions.Manool induced endothelium-independent vasorelaxation mediated by the NO/cGMP signaling pathway in rat aorta and lowered blood pressure. |
体外活性 | Manool 对 HeLa 细胞和 U343 细胞表现出较高的细胞毒活性,对两者的 IC50 均为 6.7 µg/mL。[1] Manool 对 HepG2 细胞中 MMS 诱导的染色体损伤具有保护作用。[3] |
分子量 | 290.48 |
分子式 | C20H34O |
CAS No. | 596-85-0 |
Smiles | C[C@@]12[C@](C(C)(C)CCC1)(CCC(=C)[C@@H]2CC[C@@](C=C)(C)O)[H] |
存储 | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 80 mg/mL (275.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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