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Cyclotraxin B acetate(1203586-72-4 free base) 是 TrkB 受体的拮抗剂;抑制 BDNF 诱导的 TrkB 活性 (IC50 = 0.30 nM)。变构改变 TrkB 受体构象但不改变 BDNF 结合。防止 BDNF 引起的小鼠冷异常性疼痛。还显示在小鼠中表现出推定的抗焦虑特性。
Cyclotraxin B acetate(1203586-72-4 free base) 是 TrkB 受体的拮抗剂;抑制 BDNF 诱导的 TrkB 活性 (IC50 = 0.30 nM)。变构改变 TrkB 受体构象但不改变 BDNF 结合。防止 BDNF 引起的小鼠冷异常性疼痛。还显示在小鼠中表现出推定的抗焦虑特性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,000 | 现货 | |
5 mg | ¥ 2,270 | 现货 | |
10 mg | ¥ 3,270 | 现货 | |
25 mg | ¥ 5,050 | 现货 | |
50 mg | ¥ 6,780 | 现货 | |
100 mg | ¥ 9,180 | 现货 | |
200 mg | ¥ 12,300 | 现货 |
产品描述 | Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice. |
靶点活性 | TrkB:0.30 nM |
分子量 | 1260.42 |
分子式 | C50H77N13O19S3 |
存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 10 mM | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
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