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IL-17RA Protein, Mouse, Recombinant (His)
产品编号 TMPY-01849
IL-17RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.8 kDa and the accession number is Q60943.
IL-17RA Protein, Mouse, Recombinant (His)
产品编号 TMPY-01849
IL-17RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.8 kDa and the accession number is Q60943.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μg | ¥ 3,820 | 5日内发货 | |
| 1 mg | ¥ 24,900 | 5日内发货 |
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| 生物活性 | 1. Measured by its binding ability in a functional ELISA.
2. Immobilized recombinant human IL17A at 2 μg/ml (100 μl/well) can bind biotinylated mouse IL17RA with a linear range of 1.28-6.4 ng/ml. |
| 产品描述 | IL-17RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.8 kDa and the accession number is Q60943. |
| 种属 | Mouse |
| 表达系统 | HEK293 Cells |
| 标签 | C-His |
| 蛋白编号 | Q60943 |
| 别名 | VDw217,interleukin 17 receptor A,Il17r,Cdw217,AW538159 |
| 蛋白构建 | A DNA sequence encoding the mouse IL17RA (NP_032385.1) extracellular domain (Met 1-Trp 322) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Ser 32 |
| 蛋白纯度 | > 98 % as determined by SDS-PAGE |
| 分子量 | 34.8 kDa (predicted); 55-60 kDa (reducing condition, due to glycosylation) |
| 内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| 复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| 存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. |
| 研究背景 | Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails, and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. |
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