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TWEAK/TNFSF12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is O54907.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μg | ¥ 1,950 | 5日内发货 | |
500 μg | ¥ 12,700 | 5日内发货 |
生物活性 | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
产品描述 | TWEAK/TNFSF12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is O54907. |
种属 | Mouse |
表达系统 | HEK293 Cells |
标签 | N-hFc |
蛋白编号 | O54907 |
别名 | tumor necrosis factor (ligand) superfamily, member 12,Apo3l,Tweak,Dr3lg,Dr3l |
蛋白构建 | The Mouse Tnfsf12 (NP_035744.1) (Arg105-His249) was expressed with the Fc region of Human IgG1 at the N-terminus. |
蛋白纯度 | > 85 % as determined by SDS-PAGE |
分子量 | 44.4 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM MES, 150 mM Nacl, 10% Glycerol, 0.02% Tween20, 10% Trehalose, pH 6. 0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 | In general, Lyophilized powders are shipping with blue ice. |
研究背景 | TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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