Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His)

产品编号 TMPY-02566

Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is P05014.

Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His)

产品编号 TMPY-02566

Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is P05014.

规格	价格	库存	数量
100 μg	¥ 2,940	现货

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产品信息

生物活性	Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV). The ED50 for this effect is typically 2-8 pg/mL.
产品描述	Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is P05014.
种属	Human
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	P05014
别名	干扰素,MGC142200,interferon, α4,interferon, alpha 4,INFA4,IFN-α4a,IFN-alpha4a
蛋白构建	A DNA sequence encoding the human IFNα 4a (NP_066546.1)) (Met 1-Asp 189) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Cys 24
蛋白纯度	> 88 % as determined by SDS-PAGE
分子量	20.7 kDa (predicted); 20 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, pH 7.4, 10% gly. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 and 410 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.