Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia.

α1A-adrenoceptor:4.7 nM, D2:16.6 nM, α1B-adrenoceptor:9.3 nM, α:＞100 nM, D3:27.7 nM, 5-HT1A:8 nM, 5-HT2:＞100 nM, D4:277 nM