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Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 μM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding.
Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 μM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 4,623 | 期货 | |
5 mg | ¥ 11,364 | 期货 |
产品描述 | Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 μM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding. |
体外活性 | In the cellular assay, Dolastatin 10 shows activity against some human leukaemia, lymphoma, and solid tumor cell lines (such as OVCAR-3 and NSCLC) with IC50 values ranging from 0.1nM to 10nM. It is currently tested in clinical trials [2]. |
分子量 | 899.11 |
分子式 | C44H69F3N6O8S |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: Soluble |
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