Deuterium Labeled Compounds

JNJ-6204 是一种氘代化合物，高效抑制 CSNK1D 和 CSNK1E。

Vitamin B3-d4 (Nicotinic acid-(ring-d4)) 是 Niacin 的氘代物，可用于跟踪 Niacin 在体内的代谢。

VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。

Donafenib (Bay 43-9006 (D3)) 是一种氘标记的 Sorafenib，Sorafenib 是一种多激酶抑制剂(对 Raf-1、B-Raf 和 VEGFR-3 的 IC50 分别为 6 nM、20 nM 和 22 nM)。

DL-Metanephrine-d3 Hydrochloride 是用氘原子标记的 L-Metanephrine，可用于研究 L-Metanephrine 在身体内的代谢流程。

Ursodeoxycholic Acid-d4 (Ursodeoxycholic acid-2,2,4,4-d4) 是 Ursodeoxycholic acid  的氘代物，是通过 LC MS 或 GC MS 定量检测熊去氧胆酸 （UDCA） 水平的内标。

L-838417 D9 (C-21191) 是 L-838417 的氘代物。其中L-838417 是亚型选择性GABAA 正变构调节剂，在 α2, α3 和 α5 亚型中作为部分激动剂。

Cholesterol-d6 是 Cholesterol 氘代物，可用于研究脂质膜的流动和 Cholesterol在体内的代谢情况。

Androstenedione-d7 是类固醇激素 Androstenedione 的氘代化合物，可用于研究 Androstenedione 的代谢。

Erythromycin-13C-d3 是一种 13C- 和氘代标记的 Erythromycin，可用于研究 Erythromycin 在体内的代谢流程。

3-Methoxy Dopamine-d4 Hydrochloride (3-O-methyl Dopamine-d4 hydrochloride) 是氘代标记的 Methoxytyramine hydrochloride。

Clencyclohexerol-d10 是一种氘代的 Clencyclohexerol，是 lencyclohexerol 的同位素标记物。Clencyclohexerol-d10 是一种 β-激动剂，也是动物生长促进剂。

Albendazole-d3 是一种 Albendazole 的氘代化合物，可抗蠕虫感染，可用于研究 Albendazole 在体内的代谢。

Cimbuterol-d9 是氘代标记的 Cimbuterol。Cimbuterol 是一种针对 12 β （2） -肾上腺素能激动剂。

Homovanillic acid-d5 (Vanilacetic acid-d5) 是一种氘代的 Homovanillic acid，可用于研究 Homovanillic acid 在体内的代谢。Homovanillic acid 是一种多巴胺代谢物，是灵长类动物中枢多巴胺功能的指标。

Irbesartan D4, a deuterium-labeled variant of Irbesartan, is a highly potent and specific antagonist of the angiotensin II type 1 (AT1) receptor.

Zanubrutinib-d5 是 Zanubrutinib 的氘代化合物。Zanubrutinib 的 CAS 号为 1691249-45-2。Zanubrutinib 是 Bruton tyrosine kinase(Btk) 的选择性抑制剂。

Macitentan-d4 (ACT-064992 D4) 是一种 Macitentan 氘代物，可被当作非多肽 ETA 和 ETB  (内皮素受体)双拮抗剂。Macitentan-d4 比 Macitentan 毒性更低，半衰期更长，可用于研究由内皮素受体介导介导的疾病。

DINP-d4 是 DINP 的氘代化合物。

Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor.

ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).

Dimethyl-d6 Sulfoxide 是二甲基亚砜 (DMSO, (CH3) 2S = O) 的氢 (“H”) 被另一种同位素氘 (“d”) 取代的形式。二甲基-d6 亚砜是核磁共振光谱中的常用溶剂。

Aliskiren (CGP 60536) D6 Hydrochloride is a deuterium-labeled Aliskiren. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM).

Cetirizine D4 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.

Hydroxyzine D4 is a deuterium-labeled variation of Hydroxyzine, a chemical compound known for its anticholinergic, anxiolytic, and analgesic properties. It is classified as a heterocyclic histamine H1-receptor antagonist.

Netupitant N-oxide D6 is a Netupitant metabolite, is the deuterium labeled Netupitant N-oxide.

Fluvastatin sodium is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin D6 sodium is deuterium labeled Fluvastatin sodium.

Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium-labeled Brexpiprazole S-oxide, the primary metabolite of Brexpiprazole, which is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM).

Medroxyprogesterone acetate D3 is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.

Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with antidepressant and anxiolytic.

Clomipramine D3 is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM).

Bendamustine D4 is the deuterium-labeled Bendamustine. Bendamustine is a DNA cross-linking compound with alkylating and antimetabolite properties. Bendamustine causes DNA breaks.

CTP518, a deuterated Atazanivir derivative, is a HIV protease inhibitor.

Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.

(S)-(+)-Ibuprofen D3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen ,it is an inhibitor of COX-1 and COX-2 activity (IC50s of 2.1 μM and 1.6 μM).

β-Apo-13-carotenone D3 is the deuterium labeled β-Apo-13-carotenone. β-Apo-13-carotenone is an antagonist of RXRα.

Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.

25-Hydroxy VD2-D6 is a labelled metabolite of Vitamin D2.

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. Etravirine D4 is the deuterium labeled Etravirine.

Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.

Idelalisib D5 is a deuterium-labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor.

Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from patients with lung cancer). It is selective for these phosphodiesterases over PDE1 and PDE2, where it provides less than 25% inhibition. Fenspiride potentiates the airway relaxant effects of isoproterenol and sodium nitroprusside indicating an effect on cAMP and cGMP phosphodiesterases, respectively. Aerosolized fenspiride (1 mg/ml) reverses bronchoconstriction induced by capsaicin and, when used at aerosolized concentrations ranging from 1-10 mg/ml, reduces cough induced by citric aci......

Duloxetine D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) i

DL-2-Hydroxydecanoic acid-d18 是 DL-2-Hydroxydecanoic acid 的氘代化合物。DL-2-Hydroxydecanoic acid 的 CAS 号为 37639-46-6。

Ibuprofen-d2 是 Ibuprofen 的氘代化合物。Ibuprofen 的 CAS 号为 15687-27-1。Ibuprofen 是一种丙酸衍生物和非甾体抗炎药 (NSAID)，具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂，IC50值分别为 13 和 370 μM，导致前列腺素和血栓素前体的形成减少。

Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats. It reduces blood pressure and increases heart rate in renal hypertensive rabbits. Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs. Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.

DL-2-Aminooctanoic acid-d14 是 DL-2-Aminooctanoic acid 的氘代化合物。DL-2-Aminooctanoic acid 的 CAS 号为 644-90-6。DL-2-AMINOOCTANOIC ACID 也称为α-氨基辛酸或α-氨基辛酸，属于称为α-氨基酸的有机化合物。

Deutetrabenazine metabolite M4 is believed to be related to its effect as a reversible depletion of monoamines from nerve terminals. The major circulating metabolites of Deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake