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Milademetan HCl (1398568-47-2 free base)
还可以产品编号 T28038
别名 Milademetan HCl, DS-3032b, DS3032b, DS-3032, DS3032, DS 3032b, DS 3032
Milademetan is a potent and selective MDM2 inhibitor. MDM2 inhibitor DS-3032b binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53 upon oral administration. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.
Milademetan HCl (1398568-47-2 free base)
还可以产品编号 T28038 别名 Milademetan HCl, DS-3032b, DS3032b, DS-3032, DS3032, DS 3032b, DS 3032
Milademetan is a potent and selective MDM2 inhibitor. MDM2 inhibitor DS-3032b binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53 upon oral administration. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 mg | 询价 | 期货 | |
| 500 mg | 询价 | 期货 |
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| 产品描述 | Milademetan is a potent and selective MDM2 inhibitor. MDM2 inhibitor DS-3032b binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53 upon oral administration. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis. |
| 别名 | Milademetan HCl, DS-3032b, DS3032b, DS-3032, DS3032, DS 3032b, DS 3032 |
| 分子量 | 654.99 |
| 分子式 | C30H35Cl3FN5O4 |
| 密度 | no data available |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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