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YCH3124(compound Z33)作为一种有效的USP7抑制剂(IC50=41.9 nM),显示出显著的抗肿瘤活性。该化合物对包括LNCaP(IC50= 3.6 nM)和CHP-212(IC50=9.9 nM)在内的多种肿瘤细胞表现出强大的体外抗增殖效果。YCH3124还能通过阻断G1期的细胞周期进程,从而诱导CHP-212细胞发生凋亡(apoptosis)。
YCH3124(compound Z33)作为一种有效的USP7抑制剂(IC50=41.9 nM),显示出显著的抗肿瘤活性。该化合物对包括LNCaP(IC50= 3.6 nM)和CHP-212(IC50=9.9 nM)在内的多种肿瘤细胞表现出强大的体外抗增殖效果。YCH3124还能通过阻断G1期的细胞周期进程,从而诱导CHP-212细胞发生凋亡(apoptosis)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | YCH3124 (compound Z33) is an inhibitor of USP7, exhibiting anti-tumor activity with an IC50 value of 41.9 nM. This compound demonstrates substantial in vitro anti-proliferative effects on various tumor cells, including LNCaP (IC50= 3.6 nM) and CHP-212 (IC50=9.9 nM). Moreover, YCH3124 induces apoptosis in CHP-212 cells by disrupting the cell cycle process during the G1 phase. |
靶点活性 | USP7:41.9 nM |
分子量 | 530.61 |
分子式 | C30H34N4O5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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