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Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂,通过竞争性的与钾离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI),通过减少胃酸的产生而起作用,可用于治疗胃酸相关疾病,如胃食管反流病(GERD)和消化性溃疡。
Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂,通过竞争性的与钾离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI),通过减少胃酸的产生而起作用,可用于治疗胃酸相关疾病,如胃食管反流病(GERD)和消化性溃疡。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 443 | 现货 | |
5 mg | ¥ 1,150 | 现货 | |
10 mg | ¥ 1,660 | 现货 | |
25 mg | ¥ 2,580 | 现货 | |
50 mg | ¥ 3,490 | 现货 | |
100 mg | ¥ 4,630 | 现货 | |
200 mg | ¥ 6,250 | 现货 |
产品描述 | Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activation. Abeprazan hydrochloride is a proton pump inhibitor (PPI) that acts by reducing gastric acid production and is used to treat gastric acid-related disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcers. |
体外活性 | Abeprazan hydrochloride的作用机制是可逆地结合到H+, K+-ATPase上。与PPIs不同,Abeprazan hydrochloride 不需要酸性环境来激活化合物[1]。 |
体内活性 | Abeprazan hydrochloride 以剂量依赖的方式抑制酸分泌。在应用了幽门结扎大鼠、大鼠胃腔灌流模型及Heidenhain囊狗模型的多项体内研究中,Abeprazan hydrochloride 对胃酸分泌的抑制效果等同于或优于已获批准的P-CAB化合物vonoprazan[1]。 |
别名 | 非苏拉赞盐酸盐, Fexuprazan hydrochloride, DWP14012 hydrochloride |
分子量 | 446.87 |
分子式 | C19H18ClF3N2O3S |
CAS No. | 1902954-87-3 |
Smiles | Cl.CNCc1cn(c(c1OC)-c1ccc(F)cc1F)S(=O)(=O)c1cccc(F)c1 |
密度 | 1.31g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 40 mg/mL (89.51 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
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