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Extracellular Death Factor TFA(EDF TFA)是一种线性五肽,由通讯细胞产生和释放,当达到足够的浓度时会激活细胞亚群中的细胞死亡途径。EDF TFA对极端pH值、高温和其他压力条件很敏感。在2.5 ng/ml的浓度下,EDF已被证明可以促进mazeEF(细菌内的毒素-抗毒素系统)介导的细胞死亡,促进MazF毒素的内切核酸酶活性,导致细菌mRNA的降解,显著减少大肠杆菌培养物中的种群大小。
Extracellular Death Factor TFA(EDF TFA)是一种线性五肽,由通讯细胞产生和释放,当达到足够的浓度时会激活细胞亚群中的细胞死亡途径。EDF TFA对极端pH值、高温和其他压力条件很敏感。在2.5 ng/ml的浓度下,EDF已被证明可以促进mazeEF(细菌内的毒素-抗毒素系统)介导的细胞死亡,促进MazF毒素的内切核酸酶活性,导致细菌mRNA的降解,显著减少大肠杆菌培养物中的种群大小。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 298 | 现货 | |
5 mg | ¥ 686 | 现货 | |
10 mg | ¥ 983 | 现货 | |
25 mg | ¥ 1,680 | 现货 |
产品描述 | Extracellular Death Factor TFA (EDF TFA) is a linear pentapeptide that is produced and released by communicating cells and activates cell death pathways in cellular subpopulations when sufficient concentrations are reached.EDF TFA is sensitive to extreme pH, high temperatures, and other stressful conditions. At a concentration of 2.5 ng/ml, EDF has been shown to promote mazeEF (toxin-antitoxin system within bacteria) mediated cell death, promote the endonuclease activity of MazF toxin, lead to degradation of bacterial mRNA, and significantly reduce population size in E. coli cultures. |
体外活性 | 色氨酸可能是Extracellular Death Factor TFA羟基自由基清除活性的关键残基,Extracellular Death Factor TFA 可以保护大肠杆菌免受杀菌抗生素的杀死,但不能保护 DNA 损伤或抑菌抗生素的杀死。[1] |
别名 | Extracellular Death Factor TFA(960129-66-2 Free bse), EDF TFA |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: 100 mg/mL, Sonication is recommended. ![]() |
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