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Bifluranol (BX341) 具有抗雄激素活性,在体内实验中显示出显著的抗前列腺活性,可用于治疗良性前列腺增生 (BPH)。
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Bifluranol (BX341) 具有抗雄激素活性,在体内实验中显示出显著的抗前列腺活性,可用于治疗良性前列腺增生 (BPH)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,490 | 现货 | |
5 mg | ¥ 3,790 | 现货 | |
10 mg | ¥ 5,430 | 现货 | |
25 mg | ¥ 8,160 | 现货 | |
50 mg | ¥ 10,800 | 现货 | |
100 mg | ¥ 14,800 | 现货 | |
200 mg | ¥ 19,600 | 现货 |
产品描述 | Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostatic hyperplasia (BPH). |
体内活性 | Bifluranol has been studied for its absorption, distribution, and excretion in mouse, rat, ferret, and dog. Following oral administration, Bifluranol is readily absorbed, but its blood concentrations are low due to hepatic uptake and biliary excretion. After the intravenous administration of [3H]Bifluranol at doses of 200 μg/kg in rats and 60 μg/kg in ferrets, the blood concentrations of 3H decline rapidly during the first 2 to 3 hours. The decrease is more rapid in females (18 min for rats, 30 min for ferrets) than in males (1.0 h for rats, 1.4 h for ferrets). This initial rapid decline is followed by a much slower decrease (40 h for rats, 20 h for ferrets) to concentrations at 96 hours of less than 15 ng Bifluranol equivalents mL-1 (rat) or 1 ng Bifluranol equivalents mL-1 (ferret)[1]. |
别名 | BX341 |
分子量 | 292.32 |
分子式 | C17H18F2O2 |
CAS No. | 34633-34-6 |
Smiles | CC[C@H]([C@H](C)c1ccc(O)c(F)c1)c1ccc(O)c(F)c1 |
密度 | 1.221g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 90 mg/mL (307.88 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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