L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents the formation of neurofibrillary tangles by inhibiting tau phosphorylation. L-Clausenamide has neuroprotective activity and can be used to modulate stimuli triggered by Aβ25-35. L-Clausenamide can be used to study neurological disorders like Alzheimer's disease.

在Aβ25-35处理的PC12细胞中，L-Clausenamide（10和100 μM）通过逆转由Aβ25-35刺激引起的[Ca2+]i水平过量，并减少Aβ介导的PC12细胞凋亡来展现其保护效果[3]。该化合物还能抑制p38 MAPK的磷酸化，下调P53和剪切Caspase-3的表达，以及Bax/Bcl-2的比率[3]。