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CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST)

产品编号 TMPY-04372

别名: CK2 α/CSNK2A1, CKII, CSNK2A3, CK2A1, casein kinase 2, α1 polypeptide, casein kinase 2, alpha 1 polypeptide

CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 71.4 kDa and the accession number is P68400-1.

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CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST)

规格	价格/CNY		货期	数量
50 μg	￥ 3,170		5日内发货

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参考文献

生物活性	The specific activity was determined to be 9 nmol/min/mg using casein as substrate.
产品描述	CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 71.4 kDa and the accession number is P68400-1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	N-GST
蛋白编号	P68400-1
别名	CK2 α/CSNK2A1, CKII, CSNK2A3, CK2A1, casein kinase 2, α1 polypeptide, casein kinase 2, alpha 1 polypeptide
蛋白构建	The Human CSNK2A1 isoform 1 (NP_808227.1) (Met 1-Gln 391) was fused with the GST tag at the N-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	71.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM GSH, pH 8.0.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Casein kinase II (CSNK2A1) is a constitutively active, ubiquitously expressed serine / threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CSNK2A1 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CSNK2A1, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CSNK2A1 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CSNK2A1 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

参考文献

1. Schlpfer J,et al.(1997) A radiation hybrid framework map of bovine chromosome 13. Chromosome Res. 5(8): 511-9. 2. Wirkner U,et al.(1994) The human gene (CSNK2A1) coding for the casein kinase II subunit alpha is located on chromosome 20 and contains tandemly arranged Alu repeats. Genomics. 19(2): 257-65. 3. Wirkner U,et al.(1998) Genomic organization and promoter identification of the human protein kinase CK2 catalytic subunit alpha (CSNK2A1). Genomics. 48(1): 71-8.

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Keywords

CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST) CK2 α/CSNK2A1 casein kinase 2, α 1 polypeptide casein kinase 2, a 1 polypeptide CKII CSNK2A3 CK2A1 casein kinase 2, α1 polypeptide casein kinase 2, alpha 1 polypeptide recombinant recombinant-proteins proteins protein

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