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EBI2/GPR183

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.[5] This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41.[6] This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.[5]

  • ML401
    T82341597489-14-9
    ML401 是EBI2(也称为GPR183)的选择性拮抗剂(IC50:1.03 nM)。它在趋化性分析中显示活性 (IC50:6.24 nM)。它表现出良好的稳定性,且无细胞毒性。可用作化学探针。
    • ¥ 1050
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    TargetMol | Inhibitor Sale
  • NIBR189
    T71561599432-08-2
    NIBR189是 EBI2(GPR183)小分子拮抗剂(IC50:11 nM)。
    • ¥ 231
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    TargetMol | Inhibitor Sale
  • 7α,25-Dihydroxycholesterol
    T1406364907-22-8
    7α,25-Dihydroxycholesterol 是一种孤儿 GPCR 受体EBI2 (GPR183)的内源性配体和有效选择性激动剂。它对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。它能够作为一种趋化因子,指导 B 细胞、T 细胞和树突状细胞的迁移。
    • ¥ 1212
    35日内发货
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