Namoline

Name: Namoline
Brand: TargetMol
SKU: T40420
Price: 333 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T40420Cas号 342795-11-3

别名 萘莫胺

Namoline is a γ-pyrone compound that functions as a selective and reversible inhibitor of Lysine-specific demethylase 1 (LSD1) with an IC50 of 51 μM in an HRP-coupled enzymatic assay. By impairing LSD1 demethylase activity, Namoline effectively inhibits cell proliferation. Due to its characteristics, Namoline holds promise for research pertaining to androgen-dependent prostate cancer.

Namoline

还可以

产品编号 T40420 别名 萘莫胺Cas号 342795-11-3

规格	价格	库存	数量
25 mg	¥ 10,600	6-8周

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产品介绍

生物活性

产品描述	Namoline is a γ-pyrone compound that functions as a selective and reversible inhibitor of Lysine-specific demethylase 1 (LSD1) with an IC50 of 51 μM in an HRP-coupled enzymatic assay. By impairing LSD1 demethylase activity, Namoline effectively inhibits cell proliferation. Due to its characteristics, Namoline holds promise for research pertaining to androgen-dependent prostate cancer.
体外活性	Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells[1]. Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells[1]. Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions[1].
体内活性	Namoline (0.02 mg;ip; daily) severely blunts xenograft tumor growth in nude mice with LNCaP cells[1].
别名	萘莫胺